PRIONS and the Zombie Disease!

Writers-blockImagine designing a murder mystery plot using a substance that transformed ordinary people into zombies and then writing a convincing story based on the science of it all.

The victims in your story would have difficulty walking because of loss of coordination skills and severe muscle twitching. They would draw up their armszombies-1 and shiver. They would slur their speech and act agitated. They would look emaciated and sick because they’d have trouble chewing and swallowing. If this sounds like a zombie description, I’d have to give a dramatic “Yes” answer!

In reality, however, I would be describing a person with a disease known as kuru. It’s extremely rare, but always fatal. The disease reached its peak in the late 1950s and early 1960s in New Guinea and is primarily a neurological disease that presents when infectious, abnormal proteins invade the brain.

These abnormal proteins are called prions—misshapen protein particles that form when normal proteins misfold and clump together.

The Fore people of New Guinea contracted the kuru disease because of their cannibalistic funeral rituals. They ate the brains of dead relatives during funeral rites. But it’s not the tribe’s cannibalism itself that caused the disease. It’s the fact that the consumed brain matter contained the prions already and they were transmitted orally within the brain matter.

Present day science tells us that prions are amyloid particles that form from PrionReplicationnormal brain proteins and may contribute to such diseases as Alzheimer’s, Parkinson’s and Huntington’s. Scientists describe a prion as the smallest infectious disease-causing agent and also the most indestructible biological entity.

Prions are responsible for bovine spongiform encephalopathy (known as mad cow disease) and its human counterpart, Creutzfeldt-Jacob disease. There are no generally accepted treatments for these infections and they are almost always fatal.

Initially, people with prion body accumulations in the brain experience neurological degenerations that exhibit as behavioral and personality changes, dementia and muscle coordination difficulties. The symptoms progress to convulsions and eventually to death.

Besides consuming contaminated brain matter, these encephalopathy diseases can be transmitted via blood transfusions, intravenous immunoglobulin therapies and human growth hormone treatments that have been contaminated with or contain prion bodies. Contaminated surgical instruments and organs for transplant can also transmit prion bodies.

It should be noted, however, that tests for such abnormalities have become standard practice during blood collection and prior to organ transplantation. So how could you design a murder, or a catastrophic epidemic for that matter, around the transmission of prions?

Articles that discuss the science behind a would-be zombie invasion suggest that attaching138-microscopes-lg a prion to a virus that could spread quickly and carry the prions to the frontal lobe and cerebellum could be effective. It’s been suggested that any virus that causes encephalitis would do—herpes, enteroviruses, mosquito and tick-borne viruses, rabies and even some so-called childhood diseases like mumps and measles.

Dr. Jay Fishman, Director of Transplant Infectious Diseases at Mass General Transplant Center in Boston, however, states that attaching a prion to a common virus is “a fairly unlikely scenario.”

I suspect that some clever genetic alteration of a virus would be in order here to make such an event believable to create a scientifically based zombie plague or a zombie-like murder, but I’ll leave those specific details up to you.

Thoughts? Comments? I’d love to hear them!

About James J. Murray, Fiction Writer

With experience in both pharmaceutical manufacturing and clinical patient management, medications and their impact on one’s quality of life have been my expertise. My secret passion of murder and mayhem, however, is a whole other matter. I’ve always loved reading murder mysteries and thrillers, and longed to weave such tales of my own. Drawing on my clinical expertise as a pharmacist and my infatuation with the lethal effects of drugs, my tales of murder, mayhem and medicine will have you looking over your shoulder and suspicious of anything in your medicine cabinet.
This entry was posted in A How To Blog on Murder Plot Ideas, A How To Blog on Murder Weapons, Abnormal Protein Invasion of the Brain, About James J. Murray, About Murder, All About Murder, Blog Writers, Blogging, Bloodless Death Scene Writing, Characteristics of Murder, Chemicals Used For Murder, Deciding How to Kill Off a Character in a Novel, Designer Poisons Used For Murder, Designing Murder Plots, Dramatic Murder Weapons, How to Choose a Murder Weapon for a Plot Idea, Ideas for Murder Scenes, Interesting Murder Weapons, Kuru, Microbes Used To Murder, Murder With Drugs, Neuroscience and Murder, New Methods of Murder, New Methods To Kill Characters in Your Novel, Plotting Interesting Murder Scenes, Plotting Murder Scenes, Prion Linked Diseases, Prions and Murder, Prions and Neurological Degeneration, Prions and The Science of Murder, Prions and the Zombie Disease, Science-Based Zombies, The Science of Murder, The Zombie Disease, Unique Lethal Compounds, Unique Murder Plots, Ways To Kill, Ways to Murder, Writing Death Scenes, Zombie Drugs and tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , . Bookmark the permalink.

7 Responses to PRIONS and the Zombie Disease!

  1. Jim says:

    Interesting thoughts and well written.
    Better back off the scrambled eggs
    with calf brains. The prions will
    get us.

  2. sciencethriller says:

    Oooo, that is totally the kind of scientific trick I use in my stories. Plausible enough!

    Actually I’ve read several science thrillers that use prion disease in the plot. The best was a 2006 thriller COLD PLAGUE by Daniel Kalla, a real-life physician. (My review of the book is here: )There’s a bit of prion science in James Rollins’ new Sigma Force novel THE SIXTH EXTINCTION. The challenge with using a prion as a biological weapon is partly the delivery, but also the very long time scale before symptoms develops (at least months, often years).

  3. My father was stationed in New Guinea during WWII. He was in charge of a field hospital, the triage nurse, a Master Sgt. with a stubborn sense of fair play. He told me a tale of a “curse” known as “the laughing death,” and how it was “cast” by a local witch doctor. I’m interested in retelling his story, but darkening it into a sort of scientific detective story. All my experience has been in poetry and I am afraid of the attempt, but always believed you should do things that make you afraid.

    • Phil: I encourage you to write that story! I was born and raised in New Orleans and that rich cultural history laced with some voodoo folklore should make for an interesting tale. As you may know, one of the symptoms of Kuru is uncontrolled laughing.
      I have never written good poetry. I’m told the trick is to take out the unimportant words in a short story. My attempts prove that the process is easier said than done. The best of luck in your writing.

      • Phil Boiarski says:

        James, thanks for taking time to reply. I have ab out eight irons in the fire right now but this one has a lot going for it.

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