Using Bacteria for Weight Control

Since I have a Master’s Degree in Nutrition, I was asked by my running club to give a talk this week to our training teams. The subject is proper nutrition for the long-distance runner. While researching information for that talk, I came across an interesting article in the New York Times.

The article stated that the types and amounts of bacteria we have in our intestinal tract help determine if we become fat or remain thin.

It’s an interesting concept to imagine—that we might be able to manipulate intestinal microbes to prevent obesity.

A couple of years ago, I wrote a blog about just such a subject and I’d like to share that information with you again because it seems to be gaining credibility in the scientific world of weight loss techniques.

The current belief is that being overweight is simply a math issue. If you consume more calories than you use, you gain weight. If you consume fewer calories than needed, you lose weight. The science is simple, but the execution of that is more difficult—for instance, I can never resist a piece of chocolate cake!

Now we may have a better answer. In 2005, Dr. Jeffery Gordon of Washington University in St. Louis began to investigate the relationship between diet, gut microbial ecology and obesity. By using mice in experiments, he found that the two main intestinal bacteria in mice are the same as in the human intestinal tract: Firmicutes and Baceroidetes.

As his research progressed, he discovered that obese mice had a greater amount of Firmicutes bacteria, while thin mice had more Bacteroidetes bacteria.

Armed with this information, the research team gathered two sets of germ-free mice and infected one group with microbes taken from obese mice and infected the other group with bacteria from leaner mice. Both groups were fed the exact same diet.

The results showed that the mice given bacteria from the obese mice gained excessive weight. Specifically, two weeks after exposure to the obese mice bacteria, this group had a 47 percent increase in body fat. Conversely, the group of mice infected with bacteria from the thin group had only a 27 percent increase in body fat.

These results suggest that specific microbes absorb more energy from food and that the microbial mix in our GI tract determines if we gain weight.

In layman’s terms, the microbes associated with obesity required little food and energy to reproduce and thus transferred more calories to the host (more than the host needed to maintain weight).

In contrast, microbes that kept the mice thin required far more calories to survive, leaving less for the host mice to process and use for energy. Therefore, these mice remained thin.

These studies, although still difficult to extrapolate to humans at this point, suggest that one person might have bacteria in their intestinal tracts that consume more calories, leaving that person thinner. Whereas, another person might have a different bacterial mix and gain weight by consuming similar daily calories.

The studies make a strong argument that one day we might maintain our optimal weight simply by adjusting the microbes in our intestinal tracts.

The thought of having a second piece of chocolate cake without having to worry about gaining weight absolutely makes me smile—and it makes me hungry for a piece of that cake!

Thoughts? Comments? I’d love to hear them!

About James J. Murray, Fiction Writer

With experience in both pharmaceutical manufacturing and clinical patient management, medications and their impact on one’s quality of life have been my expertise. My secret passion of murder and mayhem, however, is a whole other matter. I’ve always loved reading murder mysteries and thrillers, and longed to weave such tales of my own. Drawing on my clinical expertise as a pharmacist and my infatuation with the lethal effects of drugs, my tales of murder, mayhem and medicine will have you looking over your shoulder and suspicious of anything in your medicine cabinet.
This entry was posted in About James J. Murray, About Medications/Pharmacy, Baceroidetes Bacteria, Baceroidetes Bacterial Studies, Bacteria and Obesity, Bacteria for Weight Control, Blog Writers, Blogging, Designer Diets, Firmicutes Bacteria, Firmicutes Bacterial Studies, Friendly Bacteria, GI Tract Bacteria and Obesity, Gut Bacteria For Weight Control, Gut Microbiomes and Obesity, Human Enterotypes, Intestinal Bacteria and Obesity, Intestinal Bacteria and Weight Control, Intestinal Microbes and Obesity, Intestinal Microbes and Weight Control, Intestinal Microbes to Control Weight, James J. Murray Blog, New Blog and tagged , , , , , , , , , , , , , , , , , , , , , , , , , . Bookmark the permalink.

3 Responses to Using Bacteria for Weight Control

  1. Jim Burk says:

    I read your BLOG this AM and it caused me to respond with a BLOG to you on the word CANTOS….jb

  2. Got it in my email box, Jim. THANKS – sounds interesting!

  3. Karina says:

    Great article Jim! The impact of gut bacteria on our overall well being (weight included) has long been neglected. Closely related is the subject of overprescription of antibiotics in our country. During my own “Pavlov” experiment I started refusing to give my dogs the prescribed antibiotics after their routine dentals. (To the very dismay of my vet and his staff). Those were prescribed to “prevent” possible infection from the bacteria in the dog’s plaque that is accidentally swallowed during the cleaning. (Chances of that are minimal in a healthy dog in my opinion). However, it did stop the insatiable / abnormal hunger I had noticed in the past that my dogs were experiencing after their 10 – 12 day courses of oral antibiotics post cleaning. Coincidence?!? 🙂

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