New Superbugs and New Defenses

In response to multiple news stories over the recent years about the invasion of superbugs, defined as those bacteria resistant to almost all forms of antibiotic therapy, I’ve written blogs HERE and HERE about the invasion of superbugs that hamper our medical professionals from effectively treating infections that were once easily eradicated with broad-spectrum antibiotics.

Subsequently, I wrote a blog about a “post antibiotic era” HERE, which indicated that few new antibiotic discoveries are happening to combat the increasing number of bacteria that develop resistance to our most reliable antibiotic therapies.

Approximately, 35,000 Americans die each year from drug resistant bacterial infections. Worldwide that number climbs to a staggering 700,000 deaths each year. According to United Nations estimates, the number of deaths from drug-resistant infections could rise to 10 million humans by 2050.

We are presently in what scientists call “an antibiotic discovery void” in which more of our common bacterial infections (UTI’s, common respiratory infections, ear and throat infections, etc,) are evolving to be resistant to currently available antibiotics. This drug resistance evolution is happening much faster than medical science can discover and bring to market new drug therapies to combat those resistant bacteria.

Over this last year, I’ve been reading about some exciting and rather innovative research into a technique called “Crispr,” which could become the next generation of our fight over drug-resistant bacteria, and possibly even those stubborn viruses—many of which are immune to drug therapy (think the common cold virus).

Scientists have discovered that, in nature, Crispr is a natural gene-editing tool in a specialized region of DNA and used by bacteria to evolve and protect itself against deadly viruses. Researchers have taken that natural Crispr tool and discovered how to alter or edit other DNA to a specific use.

By using Crispr-associated enzyme technology, scientists (at least in a laboratory environment) have been able to kill a species of Salmonella bacteria. This cutting-edge research is the beginning of a significant new way of thinking for future antibiotic therapies that can target highly specific, and highly aggressive, drug-resistant bacteria.

Although the results of this research are proving to be extremely effective in the laboratory, the next step is testing in living animals and then in human trials. We may be years away from having such treatments commonly available, but hope is on the horizon that the devastating effects of a “post antibiotic era” and the prediction of “an antibiotic discovery void” may well be a thing of the past rather than a future reality.

From an author’s perspective, however, such new research in the hands of a fictional villain could create an entirely new future for the human race—at least in a sinister thriller plot to alter the balance of world power.

Thoughts? Comments? I’d love to hear them!

For some interesting and entertaining reading, download my two medical thriller novels in the Jon Masters Thriller Series.

Both involve Murder, Mayhem and Medicine!


Lethal Medicine: “When a drug study clinical trial involves more than cutting-edge research and innocent people’s lives are threatened.”

eBook or Paperback – Order Here!


Imperfect Murder: “When trust in our nation’s drug delivery system is shaken to its core and worldwide drug safety is threatened.”

eBook or Paperback – Order Here!

About James J. Murray, Fiction Writer

With experience in both pharmaceutical manufacturing and clinical patient management, medications and their impact on one’s quality of life have been my expertise. My secret passion of murder and mayhem, however, is a whole other matter. I’ve always loved reading murder mysteries and thrillers, and longed to weave such tales of my own. Drawing on my clinical expertise as a pharmacist and my infatuation with the lethal effects of drugs, my tales of murder, mayhem and medicine will have you looking over your shoulder and suspicious of anything in your medicine cabinet.
This entry was posted in A How To Blog on Murder Plot Ideas, A Jon Masters Novel, A New Novel By James J. Murray, A New Science Thriller Novel, A Thriller Novel, About James J. Murray, About Medications/Pharmacy, About Murder, All About Writing, Antibiotic Overuse, Antibiotic Resistance, Antibiotic Resistant Bacteria, Bacteria Resistant to Antibiotic Therapy, Blog Trends, Blog Writers, Blogging, CRE Prevention, Crispr and Drug Development Technology, Crispr Technology, Crispr Technology to Fill the Antibiotic Discover Void, Curing Viral Infections, Cutting Edge Drug Therapy Research, Designing Murder Plots, Developing Story Plots, Developing Storyline Ideas, Drug Resistant Carbapenem Bacteria, Drug-Resistant Bacteria, Drugs For Murder Plots, Drugs Used For Murder, Fiction Based on Facts, Fiction Based on Real Life, Future of Drug Manufacturing, How to Choose a Murder Weapon for a Plot Idea, Imperfect Murder The Novel, Imperfect Murder Thriller Novel, Ineffective Antibiotic Therapy, Ineffective Antibiotics, James J. Murray Blog, James J. Murray's IMPERFECT MURDER Novel, James J. Murray's LETHAL MEDICINE Novel, Killing Off Characters in Your Novel, Lethal Bacteria, Lethal Medicine, Lethal Medicine Thriller Novel, Medical Technology Advances, Murder Mayhem and Medicine, New Blog, New Drug Discoveries, New Drug Manufacturing Methods, New Drug Research, New Medical Thrillers, Pharmacy/Pharmaceuticals, Plot Development, Plot Ideas and Where They Come From, Plotting The Perfect Murder, Prescription For Murder Blog, Publishing A Novel, The Antibiotic Discovery Void, The Pharmacy Profession, The Post-Antibiotic Era and tagged , , , , , , , , , , , , , , , , , , , , , , , , . Bookmark the permalink.

2 Responses to New Superbugs and New Defenses

  1. Thank you James for that nice crisp analysis. (Couldn’t resist)

  2. Lol, thanks for your wonderful comment.
    All the best!!

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s